Guidelines for Using Thiazolidinediones
Type of Drug:
Oral antidiabetic (blood sugar lowering) agent used in the management of type 2 diabetes (adult-onset; non-insulin-dependent diabetes mellitus [NIDDM]) not adequately controlled with diet and exercise.
How the Drug Works:
The thiazolidinedione hypoglycemic agents appear to lower blood sugar (glucose) by improving target cell response or sensitivity to insulin. They also decrease glucose output from the liver and increase insulin-dependent glucose disposal in skeletal muscle. They do not stimulate insulin production but lower tissue resistance (eg, increase sensitivity) to insulin.
Used alone or as an adjunct to diet and exercise to treat type 2 diabetes or in combination with a sulfonamide or insulin, or mentoring to improve glycolic control when diet, exercise, and a single diabetic drug do not accomplish adequate control of blood glucose levels.
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and potential benefits to the mother outweigh the possible hazard to the fetus. Most experts recommend that insulin be used to control diabetes during pregnancy.
Braastfeeding: It is not known if thiazolidinediones appear in breast milk. Do not administer to a nursing woman.
Children: Safety and effectiveness in patients under 18 years of age have not been established.
Lab Tests: Lab Tests will bo roqlliroci to monitor theropy Tests may include blood glucose,glycosylated,hemogolobin,and liver funtion.
Tell your doctor or pharmacist if you are taking or planning to take any overthe-counter or prescription medications or dietary supplements while taking thiazolidinediones. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. Insulin interacts with thiazolidinediones. The following drugs and drug classes interact with pioglitazone only:
Every drug is capable of producing side effects. Many thiazolidinedione users experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:
Digestive Tract: Nausea; diarrhea; weight gain.
Other: Headache; runny nose; sore throat; muscle or back pain; fluid retention; upper respiratory tract infection; elevated liver enzymes; dark urine; anemia; blood sugar changes; abnormal blood tests.
Guidelines for Use:
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