Serotonin 5-HT- Receptor Agonists
Type of Drug:
Agent for treating migraine headaches.
How the Drug Works:
Serotonin 5-HT 1 receptor antagonists constrict blood vessels in the brain and reduce transmission of trigeminal pain pathways, thus providing relief from migraine headaches.
For the acute management of migraine with or without aura in adults. Not intended for the prevention of migraine or for use in the management of hemiplegic or basilar migraine.
Sumatriptan succinate injection: For the acute treatment of cluster headache episodes.
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits outweigh the possible hazards to the fetus.
Breastfeeding: It is not known if 5-HT agonists appear in breast milk. Consult your doctor before you begin breastfeeding.
Children: Safety and effectiveness have not been established. Not recommended in patients younger than 18 years of age.
Lab Tests: Lab tests may be required prior to or during therapy. Tests include cardiovascular system evaluations.
Tell your doctor or pharmacist if you are taking or planning to take any overthe-counter or prescription medications or dietary supplements while taking these drugs. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. The following drugs or drug classes interact with these drugs:
Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:
Digestive Tract: Stomach pain; nausea; dry mouth; vomiting.
Nervous System: Drowsiness; headache; abnormal skin sensations (eg, feeling of warmth, heat, numbness, tingling); dizziness; unusual drowsiness or weakness.
Circulatory System: Increased blood pressure; chest pain, tightness, heaviness, or pressure; abnormal heart rhythm; fainting; flushing.
Other: Light sensitivity; neck, throat, or jaw pain or tightness; fatigue.
Guidelines for Use:
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